MolNFT v1 · #151036 · protein
Echovirus 18 a-particle
6HBH · Echovirus 18 capsid protein 1: “Echovirus 18 a-particle”. Electron microscopy, 6 pockets (best druggability 0.49). MolNFT v1 #151036 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6HBH
- Type
- protein
- Length
- 680 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Echovirus 18 capsid protein 1; Echovirus 18 capsid protein 2; Echovirus 18 capsid protein…
- UniProt
- Q8V635
- Pockets
- 6 · best druggability 0.49
Structure
electron microscopy · 3 distinct chains · 6% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Echovirus 18 capsid protein 1 | protein | 224 | 6% helix, 30% strand | Q8V635 |
| B | Echovirus 18 capsid protein 2 | protein | 238 | 6% helix, 30% strand | Q8V635 |
| C | Echovirus 18 capsid protein 3 | protein | 218 | 6% helix, 33% strand | Q8V635 |
Pockets
6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 127 | 0.49 | 0.80 | 25 | empty |
| 2 | 78 | 0.38 | 0.77 | 17 | empty |
| 3 | 106 | 0.37 | 0.74 | 20 | empty |
| 4 | 56 | 0.34 | 0.77 | 12 | empty |
| 5 | 54 | 0.30 | 0.76 | 19 | empty |
Interfaces
3 interfaces between chains.
- A–C · 3209 Ų buried · 37 hydrogen bonds · protein-protein
- A–B · 1625 Ų buried · 17 hydrogen bonds · protein-protein
- B–C · 1528 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6HBH · Echovirus 18 A-particle · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8V635
- Elsewhere: RCSB PDB 6HBH · PDBe 6HBH · UniProt Q8V635
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