MolNFT v1 · #15102 · protein

Structure of muconate lactonizing enzyme at 1.85 ångströms resolution

1MUC: “Structure of muconate lactonizing enzyme at 1.85 ångströms resolution”. X-ray diffraction, 1 ligand (MN), 2 pockets (best druggability 0.82). MolNFT v1 #15102 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1MUC
Type: protein
Length: 720 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Muconate lactonizing enzyme
EC: 5.5.1.1
UniProt: P08310
Ligands: MN
Pockets: 2 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Muconate lactonizing enzyme (EC 5.5.1.1)	protein	360	43% helix, 22% strand	P08310

Ligands and binding sites

MN · Manganese (II) ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	982	0.82	0.83	109	empty
2	202	0.58	0.80	33	empty

Interfaces

1 interface between chains.

A–B · 913 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

1MUC · Structure of muconate lactonizing enzyme at 1.85 ångströms resolution · the same entry in another collection · chain A against A, TM-score 1.00
P08310 · AlphaFold monomer V2.0 prediction for muconate cycloisomerase 1 (P08310) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08310
Elsewhere: RCSB PDB 1MUC · PDBe 1MUC · UniProt P08310

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