MolNFT v1 · #150937 · protein

Crystal structure of the third srcr domain of murine neurotrypsin.

6H8M: “Crystal structure of the third srcr domain of murine neurotrypsin.”. X-ray diffraction, 1 pocket (best druggability 0.40). MolNFT v1 #150937 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6H8M
Type: protein
Length: 214 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neurotrypsin
EC: 3.4.21.-
UniProt: O08762
Pockets: 1 · best druggability 0.40

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Neurotrypsin (EC 3.4.21.-)	protein	107	15% helix, 33% strand	O08762

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	139	0.40	0.74	24	empty

Interfaces

1 interface between chains.

A–B · 388 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

6H8M · Crystal structure of the third SRCR domain of Murine Neurotrypsin. · the same entry in another collection · chain A against A, TM-score 1.00
O08762 · AlphaFold monomer V2.0 prediction for neurotrypsin (O08762) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O08762
Elsewhere: RCSB PDB 6H8M · PDBe 6H8M · UniProt O08762

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