MolNFT v1 · #150840 · protein + RNA
Cryo-EM MAP of in vitro assembled measles virus N into nucleocapsid- like particles (nclps) bound to viral genomic 5-prime RNA hexamers.
6H5S: “Cryo-EM MAP of in vitro assembled measles virus N into nucleocapsid- like particles (nclps) bound to viral…”. Electron microscopy, 3 pockets (best druggability 0.61). MolNFT v1 #150840 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6H5S
- Type
- protein + RNA
- Length
- 369 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleocapsid; RNA (5'-R(*AP*CP*CP*AP*GP*A)-3')
- UniProt
- B8PZP0
- Pockets
- 3 · best druggability 0.61
Structure
electron microscopy · 2 distinct chains · 52% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Nucleocapsid | protein | 363 | 52% helix, 6% strand | B8PZP0 |
| E | RNA (5'-R(*AP*CP*CP*AP*GP*A)-3') | rna | 6 | — | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 98 | 0.61 | 0.88 | 27 | empty |
| 2 | 55 | 0.29 | 0.74 | 14 | empty |
| 3 | 51 | 0.25 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- C–E · 901 Ų buried · 17 hydrogen bonds · protein-nucleic
Compared structures
- 6H5S · Cryo-EM map of in vitro assembled Measles virus N into nucleocapsid-like particles… · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B8PZP0
- Elsewhere: RCSB PDB 6H5S · PDBe 6H5S · UniProt B8PZP0
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