MolNFT v1 · #150766 · protein
Structure of VGRG1 in the type VI secretion "pre-firing" VGRG1-TSE6- EAGT6-ef-tu-TSI6 complex
6H3L: “Structure of VGRG1 in the type VI secretion "pre-firing" VGRG1-TSE6- EAGT6-ef-tu-TSI6 complex”. Electron microscopy, 20 pockets (best druggability 0.91). MolNFT v1 #150766 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6H3L
- Type
- protein
- Length
- 1,881 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- VGRG1
- UniProt
- Q9I741
- Pockets
- 20 · best druggability 0.91
Structure
electron microscopy · 1 distinct chain · 12% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | VGRG1 | protein | 627 | 12% helix, 43% strand | Q9I741 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1150 | 0.91 | 0.93 | 135 | empty |
| 2 | 102 | 0.79 | 0.97 | 27 | empty |
| 3 | 840 | 0.79 | 0.82 | 71 | empty |
| 4 | 911 | 0.78 | 0.81 | 77 | empty |
| 5 | 254 | 0.71 | 0.86 | 30 | empty |
Interfaces
3 interfaces between chains.
- A–C · 8385 Ų buried · 221 hydrogen bonds · protein-protein
- A–B · 8238 Ų buried · 227 hydrogen bonds · protein-protein
- B–C · 8226 Ų buried · 222 hydrogen bonds · protein-protein
Compared structures
- 6H3L · Structure of VgrG1 in the Type VI secretion "pre-firing" VgrG1-Tse6-EagT6-EF-Tu-Tsi6… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9I741 · AlphaFold monomer V2.0 prediction for type VI secretion system spike protein VGRG1A… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9I741
- Elsewhere: RCSB PDB 6H3L · PDBe 6H3L · UniProt Q9I741
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