MolNFT v1 · #15073 · protein
Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
1MT9 · Protease retropepsin: “Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy”. X-ray diffraction, 1 ligand (PO4). MolNFT v1 #15073 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1MT9
- Type
- protein
- Length
- 208 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protease retropepsin; P1-P6 gag substrate decapeptide
- EC
- 3.4.23.16
- UniProt
- P03369
- Ligands
- PO4
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 55% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Protease retropepsin (EC 3.4.23.16) | protein | 99 | 4% helix, 57% strand | P03369 |
| P | P1-P6 gag substrate decapeptide | protein | 10 | 0% helix, 40% strand | — |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
3 interfaces between chains.
- A–B · 1875 Ų buried · 36 hydrogen bonds · protein-protein
- B–P · 630 Ų buried · 14 hydrogen bonds · protein-protein
- A–P · 489 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 1MT9 · Viability of a drug-resistant HIV-1 protease mutant: structural insights for better… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03369
- Elsewhere: RCSB PDB 1MT9 · PDBe 1MT9 · UniProt P03369
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.