MolNFT v1 · #15071 · protein
Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
1MT7 · Protease retropepsin: “Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy”. X-ray diffraction. MolNFT v1 #15071 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1MT7
- Type
- protein
- Length
- 206 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protease retropepsin; Substrate analogue
- EC
- 3.4.23.16
- UniProt
- P03369, Q9YYH6
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Protease retropepsin (EC 3.4.23.16) | protein | 99 | 7% helix, 55% strand | P03369 |
| P | Substrate analogue | protein | 8 | 0% helix, 38% strand | Q9YYH6 |
Ligands and binding sites
- ACT · Acetate ion · additive · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
3 interfaces between chains.
- A–B · 1822 Ų buried · 36 hydrogen bonds · protein-protein
- A–P · 485 Ų buried · 12 hydrogen bonds · protein-protein
- B–P · 465 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1MT7 · Viability of a drug-resistant HIV-1 protease mutant: structural insights for better… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03369
- Every structure of UniProt Q9YYH6
- Elsewhere: RCSB PDB 1MT7 · PDBe 1MT7 · UniProt P03369 · UniProt Q9YYH6
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