MolNFT v1 · #150505 · protein

Second pair of fibronectin type III domains of integrin BETA4 bound to the bullous pemphigoid antigen BP230 (BPAG1E)

6GVL · Integrin beta-4: “Second pair of fibronectin type III domains of integrin BETA4 bound to the bullous pemphigoid antigen BP230…”. X-ray diffraction, 2 pockets (best druggability 0.39). MolNFT v1 #150505 on GenesisL1: 3D structure…

PDB: 6GVL
Type: protein
Length: 222 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Integrin beta-4; Dystonin
UniProt: P16144, Q03001
Pockets: 2 · best druggability 0.39

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 56% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Integrin beta-4	protein	199	0% helix, 56% strand	P16144
B	Dystonin	protein	23	0% helix, 52% strand	Q03001

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	113	0.39	0.75	16	empty
2	70	0.33	0.76	21	empty

Interfaces

1 interface between chains.

A–B · 1463 Å² buried · 27 hydrogen bonds · protein-protein

Compared structures

6GVL · Second pair of Fibronectin type III domains of integrin beta4 bound to the bullous… · the same entry in another collection · chain A against A, TM-score 1.00
P16144 · AlphaFold monomer V2.0 prediction for integrin beta-4 (P16144) · a predicted model of the same protein · chain A against A, TM-score 0.59

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P16144
Every structure of UniProt Q03001
Elsewhere: RCSB PDB 6GVL · PDBe 6GVL · UniProt P16144 · UniProt Q03001

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