MolNFT v1 · #150478 · protein
Structure of CHD5 PHD2 - tandem chromodomains
6GUU · Chromodomain-helicase-DNA-binding protein 5: “Structure of CHD5 PHD2 - tandem chromodomains”. X-ray diffraction, 1 ligand (ZN), 5 pockets (best druggability 0.57). MolNFT v1 #150478 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6GUU
- Type
- protein
- Length
- 398 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromodomain-helicase-DNA-binding protein 5
- EC
- 3.6.4.12
- UniProt
- Q8TDI0
- Ligands
- ZN
- Pockets
- 5 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromodomain-helicase-DNA-binding protein 5 (EC 3.6.4.12) | protein | 194 | 26% helix, 23% strand | Q8TDI0 |
| B | Chromodomain-helicase-DNA-binding protein 5 (EC 3.6.4.12) | protein | 204 | 29% helix, 22% strand | Q8TDI0 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 329 | 0.57 | 0.76 | 29 | empty |
| 2 | 321 | 0.56 | 0.76 | 33 | empty |
| 3 | 62 | 0.35 | 0.77 | 14 | empty |
| 4 | 67 | 0.35 | 0.76 | 15 | empty |
| 5 | 75 | 0.31 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 340 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TDI0
- Elsewhere: RCSB PDB 6GUU · PDBe 6GUU · UniProt Q8TDI0
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