MolNFT v1 · #150385 · protein

Crystal structure of the light chain dimer MH6

6GRZ: “Crystal structure of the light chain dimer MH6”. X-ray diffraction, 6 pockets (best druggability 0.66). MolNFT v1 #150385 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6GRZ
Type: protein
Length: 429 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MH6
Pockets: 6 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	MH6	protein	215	9% helix, 50% strand	—
B	MH6	protein	214	7% helix, 50% strand	—

Ligands and binding sites

GOL · Glycerol · additive · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	638	0.66	0.76	59	empty
2	314	0.61	0.78	37	empty
3	287	0.56	0.76	33	empty
4	92	0.37	0.76	25	GOL
5	85	0.33	0.74	22	empty

Interfaces

1 interface between chains.

A–B · 1618 Å² buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

6GRZ · Crystal structure of the light chain dimer mH6 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6GRZ · PDBe 6GRZ

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