MolNFT v1 · #15038 · protein
Triclinic form of trypanosoma cruzi trans-sialidase
1MS4: “Triclinic form of trypanosoma cruzi trans-sialidase”. X-ray diffraction, 7 pockets (best druggability 0.58). MolNFT v1 #15038 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1MS4
- Type
- protein
- Length
- 1,246 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Trans-sialidase
- EC
- 3.2.1.18
- UniProt
- Q26964
- Pockets
- 7 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Trans-sialidase (EC 3.2.1.18) | protein | 623 | 8% helix, 48% strand | Q26964 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 250 | 0.58 | 0.78 | 26 | empty |
| 2 | 271 | 0.57 | 0.77 | 26 | empty |
| 3 | 214 | 0.56 | 0.79 | 36 | empty |
| 4 | 191 | 0.55 | 0.79 | 32 | empty |
| 5 | 78 | 0.28 | 0.72 | 21 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1MS4 · Triclinic form of Trypanosoma cruzi trans-sialidase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q26964
- Elsewhere: RCSB PDB 1MS4 · PDBe 1MS4 · UniProt Q26964
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