MolNFT v1 · #150379 · protein
Paired immunoglobulin-like receptor B (pirb) or leukocyte immunoglobulin-like receptor subfamily B member 3 (LILRB3) full extracellular domain
6GRS: “Paired immunoglobulin-like receptor B (pirb) or leukocyte immunoglobulin-like receptor subfamily B member 3…”. X-ray diffraction, 1 ligand (NAG), 12 pockets (best druggability 0.74). MolNFT v1 #150379 on GenesisL1: 3D structure…
- PDB
- 6GRS
- Type
- protein
- Length
- 1,165 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Paired immunoglobulin-like receptor B
- UniProt
- Q8K4V6
- Ligands
- NAG
- Pockets
- 12 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Paired immunoglobulin-like receptor B | protein | 578 | 2% helix, 49% strand | Q8K4V6 |
| B | Paired immunoglobulin-like receptor B | protein | 587 | 2% helix, 49% strand | Q8K4V6 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 359 | 0.74 | 0.85 | 45 | empty |
| 2 | 750 | 0.71 | 0.77 | 82 | empty |
| 3 | 123 | 0.46 | 0.79 | 23 | empty |
| 4 | 115 | 0.44 | 0.77 | 20 | empty |
| 5 | 160 | 0.43 | 0.74 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 1998 Ų buried · 33 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 6GRS · Paired immunoglobulin-like receptor B (PirB) or Leukocyte immunoglobulin-like receptor… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8K4V6
- Elsewhere: RCSB PDB 6GRS · PDBe 6GRS · UniProt Q8K4V6
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