MolNFT v1 · #150191 · protein

Crystal structure of the FIP200 C-terminal region

6GMA · RB1-inducible coiled-coil protein 1: “Crystal structure of the FIP200 C-terminal region”. X-ray diffraction, 6 pockets (best druggability 0.78). MolNFT v1 #150191 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6GMA
Type: protein
Length: 758 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RB1-inducible coiled-coil protein 1
UniProt: Q8TDY2
Pockets: 6 · best druggability 0.78

Structure

x-ray diffraction · 6 distinct chains · 27% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RB1-inducible coiled-coil protein 1	protein	127	27% helix, 30% strand	Q8TDY2
B	RB1-inducible coiled-coil protein 1	protein	127	27% helix, 28% strand	Q8TDY2
C	RB1-inducible coiled-coil protein 1	protein	130	26% helix, 28% strand	Q8TDY2
D	RB1-inducible coiled-coil protein 1	protein	131	28% helix, 28% strand	Q8TDY2
E	RB1-inducible coiled-coil protein 1	protein	123	27% helix, 29% strand	Q8TDY2
F	RB1-inducible coiled-coil protein 1	protein	120	27% helix, 29% strand	Q8TDY2

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1150	0.78	0.80	104	empty
2	192	0.47	0.75	36	empty
3	92	0.46	0.80	21	empty
4	169	0.44	0.74	29	empty
5	139	0.44	0.75	28	empty

Interfaces

8 interfaces between chains.

C–D · 1730 Å² buried · 11 hydrogen bonds · protein-protein
A–B · 1459 Å² buried · 6 hydrogen bonds · protein-protein
E–F · 1129 Å² buried · 8 hydrogen bonds · protein-protein
D–F · 736 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 457 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

6GMA · Crystal structure of the FIP200 C-terminal region · the same entry in another collection · chain F against F, TM-score 1.00
Q8TDY2 · AlphaFold monomer V2.0 prediction for RB1-inducible coiled-coil protein 1 (Q8TDY2) · a predicted model of the same protein · chain F against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TDY2
Elsewhere: RCSB PDB 6GMA · PDBe 6GMA · UniProt Q8TDY2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.