MolNFT v1 · #150178 · protein
Structure of galectin-10 in complex with the Fab fragment of a charcot-leyden crystal solubilizing antibody, 4E8
6GLX: “Structure of galectin-10 in complex with the Fab fragment of a charcot-leyden crystal solubilizing antibody…”. X-ray diffraction, 14 pockets (best druggability 0.61). MolNFT v1 #150178 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6GLX
- Type
- protein
- Length
- 1,139 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Galectin-10; Fab 4E8 - heavy chain; Fab 4E8 - light chain
- UniProt
- Q05315
- Pockets
- 14 · best druggability 0.61
Structure
x-ray diffraction · 5 distinct chains · 4% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Galectin-10 | protein | 138 | 4% helix, 53% strand | Q05315 |
| B | Galectin-10 | protein | 137 | 4% helix, 53% strand | Q05315 |
| C | Fab 4E8 - heavy chain | protein | 224 | 3% helix, 42% strand | — |
| D, L | Fab 4E8 - light chain | protein | 213 | 7% helix, 51% strand | — |
| H | Fab 4E8 - heavy chain | protein | 214 | 3% helix, 47% strand | — |
Pockets
14 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 574 | 0.61 | 0.74 | 60 | empty |
| 2 | 380 | 0.53 | 0.73 | 53 | empty |
| 3 | 106 | 0.52 | 0.82 | 19 | empty |
| 4 | 173 | 0.50 | 0.78 | 29 | empty |
| 5 | 84 | 0.48 | 0.82 | 18 | empty |
Interfaces
7 interfaces between chains.
- H–L · 2014 Ų buried · 21 hydrogen bonds · protein-protein
- C–D · 2004 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 907 Ų buried · 16 hydrogen bonds · protein-protein
- A–L · 506 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 483 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 6GLX · Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal… · the same entry in another collection · chain L against L, TM-score 1.00
- Q05315 · AlphaFold monomer V2.0 prediction for galectin-10 (Q05315) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q05315
- Elsewhere: RCSB PDB 6GLX · PDBe 6GLX · UniProt Q05315
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