MolNFT v1 · #150177 · protein
Structure of galectin-10 in complex with the Fab fragment of a charcot-leyden crystal solubilizing antibody, 1D11
6GLW: “Structure of galectin-10 in complex with the Fab fragment of a charcot-leyden crystal solubilizing antibody…”. X-ray diffraction, 14 pockets (best druggability 0.61). MolNFT v1 #150177 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6GLW
- Type
- protein
- Length
- 1,155 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Galectin-10; Fab 1D11 - heavy chain; Fab 1D11 - light chain
- UniProt
- Q05315
- Pockets
- 14 · best druggability 0.61
Structure
x-ray diffraction · 6 distinct chains · 7% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Galectin-10 | protein | 139 | 4% helix, 54% strand | Q05315 |
| B | Galectin-10 | protein | 139 | 4% helix, 54% strand | Q05315 |
| C | Fab 1D11 - heavy chain | protein | 218 | 8% helix, 50% strand | — |
| D | Fab 1D11 - light chain | protein | 213 | 8% helix, 51% strand | — |
| H | Fab 1D11 - heavy chain | protein | 230 | 8% helix, 48% strand | — |
| L | Fab 1D11 - light chain | protein | 216 | 6% helix, 50% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 221 | 0.61 | 0.81 | 25 | empty |
| 2 | 514 | 0.58 | 0.73 | 52 | empty |
| 3 | 241 | 0.58 | 0.79 | 27 | empty |
| 4 | 235 | 0.55 | 0.77 | 33 | empty |
| 5 | 335 | 0.52 | 0.73 | 40 | empty |
Interfaces
7 interfaces between chains.
- H–L · 1916 Ų buried · 21 hydrogen bonds · protein-protein
- C–D · 1676 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 908 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 510 Ų buried · 8 hydrogen bonds · protein-protein
- A–H · 508 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 disulfide (disulfide).
Compared structures
- 6GLW · Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal… · the same entry in another collection · chain L against L, TM-score 1.00
- Q05315 · AlphaFold monomer V2.0 prediction for galectin-10 (Q05315) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q05315
- Elsewhere: RCSB PDB 6GLW · PDBe 6GLW · UniProt Q05315
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.