MolNFT v1 · #150129 · protein
Structure of E COLI mlac in variously loaded states
6GKI · Probable phospholipid-binding protein mlac: “Structure of E COLI mlac in variously loaded states”. X-ray diffraction, 1 ligand (BR), 4 pockets (best druggability 0.81). MolNFT v1 #150129 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6GKI
- Type
- protein
- Length
- 370 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable phospholipid-binding protein mlac
- UniProt
- P0ADV7
- Ligands
- BR
- Pockets
- 4 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable phospholipid-binding protein mlac | protein | 185 | 53% helix, 17% strand | P0ADV7 |
| B | Probable phospholipid-binding protein mlac | protein | 185 | 56% helix, 19% strand | P0ADV7 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 523 | 0.81 | 0.87 | 48 | empty |
| 2 | 247 | 0.56 | 0.78 | 34 | empty |
| 3 | 169 | 0.52 | 0.78 | 35 | empty |
| 4 | 55 | 0.41 | 0.82 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 571 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6GKI · Structure of E coli MlaC in Variously Loaded States · the same entry in another collection · chain A against A, TM-score 1.00
- P0ADV7 · AlphaFold monomer V2.0 prediction for intermembrane phospholipid transport system binding… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0ADV7
- Elsewhere: RCSB PDB 6GKI · PDBe 6GKI · UniProt P0ADV7
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