MolNFT v1 · #150113 · protein
Helical reconstruction of BCL10 card and MALT1 death domain complex
6GK2 · B-cell LYMPHOMA/LEUKEMIA 10: “Helical reconstruction of BCL10 card and MALT1 death domain complex”. Electron microscopy, 6 pockets (best druggability 0.69). MolNFT v1 #150113 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6GK2
- Type
- protein
- Length
- 191 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- B-cell LYMPHOMA/LEUKEMIA 10; Mucosa-associated lymphoid tissue lymphoma translocation…
- EC
- 3.4.22.-
- UniProt
- O95999, Q9UDY8
- Pockets
- 6 · best druggability 0.69
Structure
electron microscopy · 2 distinct chains · 64% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | B-cell LYMPHOMA/LEUKEMIA 10 | protein | 106 | 66% helix, 0% strand | O95999 |
| F | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) | protein | 85 | 62% helix, 0% strand | Q9UDY8 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.69 | 0.94 | 22 | empty |
| 2 | 152 | 0.65 | 0.86 | 27 | empty |
| 3 | 241 | 0.55 | 0.77 | 32 | empty |
| 4 | 65 | 0.40 | 0.79 | 13 | empty |
| 5 | 84 | 0.36 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- H–F · 652 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6GK2 · Helical reconstruction of BCL10 CARD and MALT1 DEATH DOMAIN complex · the same entry in another collection · chain H against H, TM-score 1.00
- O95999 · AlphaFold monomer V2.0 prediction for B-cell LYMPHOMA/LEUKEMIA 10 (O95999) · a predicted model of the same protein · chain H against A, TM-score 0.92
- Q9UDY8 · AlphaFold monomer V2.0 prediction for mucosa-associated lymphoid tissue lymphoma… · a predicted model of the same protein · chain F against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95999
- Every structure of UniProt Q9UDY8
- Elsewhere: RCSB PDB 6GK2 · PDBe 6GK2 · UniProt O95999 · UniProt Q9UDY8
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