MolNFT v1 · #150091 · protein

Structure of the AMNIONLESS(20-357)-CUBILIN(36-135) complex

6GJE · Protein amnionless: “Structure of the AMNIONLESS(20-357)-CUBILIN(36-135) complex”. X-ray diffraction, 5 pockets (best druggability 0.68). MolNFT v1 #150091 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6GJE
Type: protein
Length: 585 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein amnionless; Cubilin
UniProt: Q9BXJ7, O60494
Pockets: 5 · best druggability 0.68

Structure

x-ray diffraction · 4 distinct chains · 30% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein amnionless	protein	338	21% helix, 28% strand	Q9BXJ7
B	Cubilin	protein	82	43% helix, 24% strand	O60494
C	Cubilin	protein	83	46% helix, 24% strand	O60494
D	Cubilin	protein	82	39% helix, 26% strand	O60494

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	331	0.68	0.82	35	empty
2	50	0.49	0.87	15	empty
3	65	0.48	0.83	12	empty
4	167	0.43	0.74	35	empty
5	140	0.43	0.76	29	empty

Interfaces

6 interfaces between chains.

C–D · 1781 Å² buried · 33 hydrogen bonds · protein-protein
B–D · 1751 Å² buried · 24 hydrogen bonds · protein-protein
B–C · 1722 Å² buried · 23 hydrogen bonds · protein-protein
A–D · 542 Å² buried · 11 hydrogen bonds · protein-protein
A–B · 500 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

6GJE · Structure of the Amnionless(20-357)-Cubilin(36-135) complex · the same entry in another collection · chain A against A, TM-score 1.00
Q9BXJ7 · AlphaFold monomer V2.0 prediction for protein amnionless (Q9BXJ7) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BXJ7
Every structure of UniProt O60494
Elsewhere: RCSB PDB 6GJE · PDBe 6GJE · UniProt Q9BXJ7 · UniProt O60494

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