MolNFT v1 · #150088 · protein
Purple acid phytase from wheat isoform B2 - H229A mutant
6GJA · Purple acid phosphatase: “Purple acid phytase from wheat isoform B2 - H229A mutant”. X-ray diffraction, 4 ligands (NAG, BMA, FE), 7 pockets (best druggability 0.75). MolNFT v1 #150088 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6GJA
- Type
- protein
- Length
- 492 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Purple acid phosphatase
- EC
- 3.1.3.2
- UniProt
- C4PKL0
- Ligands
- NAG, BMA, FE, PO4
- Pockets
- 7 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 17% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Purple acid phosphatase (EC 3.1.3.2) | protein | 492 | 17% helix, 27% strand | C4PKL0 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A
- BMA · beta-D-mannopyranose · sugar · chains A
- FE · Fe (III) ion · metal · 2 copies · chains A
- PO4 · Phosphate ion · ion · 3 copies · chains A
- EDO · 1,2-ethanediol · additive · 8 copies · chains A
- PEG · Di(hydroxyethyl)ether · additive · 5 copies · chains A
- PGE · Triethylene glycol · additive · 3 copies · chains A
- PG6 · 1-(2-methoxy-ethoxy)-2-{2-[2-(2-methoxy-ethoxy]-ethoxy}-ethane · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.75 | 0.99 | 23 | empty |
| 2 | 54 | 0.42 | 0.83 | 20 | empty |
| 3 | 76 | 0.35 | 0.76 | 18 | EDO |
| 4 | 71 | 0.34 | 0.76 | 21 | PG6 |
| 5 | 56 | 0.32 | 0.77 | 18 | EDO |
Modifications
Observed in the structure: 7 glycan, 3 disulfide (N-glycosylation, disulfide).
Compared structures
- 6GJA · Purple acid phytase from wheat isoform B2 - H229A mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C4PKL0
- Elsewhere: RCSB PDB 6GJA · PDBe 6GJA · UniProt C4PKL0
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