MolNFT v1 · #150069 · protein

Arabidopsis thaliana cytosolic seryl-tRNA synthetase

6GIR · Serine--tRNA ligase, cytoplasmic: “Arabidopsis thaliana cytosolic seryl-tRNA synthetase”. X-ray diffraction, 4 pockets (best druggability 0.61). MolNFT v1 #150069 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6GIR
Type: protein
Length: 406 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serine--tRNA ligase, cytoplasmic
EC: 6.1.1.11
UniProt: Q39230
Pockets: 4 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11)	protein	406	41% helix, 21% strand	Q39230

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	404	0.61	0.77	40	empty
2	165	0.45	0.75	26	empty
3	109	0.45	0.78	15	empty
4	63	0.29	0.73	19	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

6GIR · Arabidopsis thaliana cytosolic seryl-tRNA synthetase · the same entry in another collection · chain A against A, TM-score 1.00
Q39230 · AlphaFold monomer V2.0 prediction for serine--tRNA ligase, cytoplasmic (Q39230) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q39230
Elsewhere: RCSB PDB 6GIR · PDBe 6GIR · UniProt Q39230

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