MolNFT v1 · #150041 · protein
Structure of lytic transglycosylase mlte mutant Y192F from E.COLI
6GHZ · Endo-type membrane-bound lytic murein transglycosylase a: “Structure of lytic transglycosylase mlte mutant Y192F from E.COLI”. X-ray diffraction, 2 pockets (best druggability 0.31). MolNFT v1 #150041 on GenesisL1: 3D structure…
- PDB
- 6GHZ
- Type
- protein
- Length
- 377 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endo-type membrane-bound lytic murein transglycosylase a
- EC
- 4.2.2.-
- UniProt
- P0C960
- Pockets
- 2 · best druggability 0.31
Structure
x-ray diffraction · 2 distinct chains · 66% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Endo-type membrane-bound lytic murein transglycosylase a (EC 4.2.2.-) | protein | 190 | 66% helix, 3% strand | P0C960 |
| A | Endo-type membrane-bound lytic murein transglycosylase a (EC 4.2.2.-) | protein | 187 | 66% helix, 3% strand | P0C960 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 74 | 0.31 | 0.74 | 16 | empty |
| 2 | 57 | 0.30 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- B–A · 745 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 6GHZ · Structure of Lytic Transglycosylase MltE mutant Y192F from E.coli · the same entry in another collection · chain B against B, TM-score 1.00
- P0C960 · AlphaFold monomer V2.0 prediction for endo-type membrane-bound lytic murein… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C960
- Elsewhere: RCSB PDB 6GHZ · PDBe 6GHZ · UniProt P0C960
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