MolNFT v1 · #150003 · protein
Structure of RIP2 card filament
6GGS · Receptor-interacting SERINE/THREONINE-protein kinase 2: “Structure of RIP2 card filament”. Electron microscopy, 7 pockets (best druggability 0.84). MolNFT v1 #150003 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6GGS
- Type
- protein
- Length
- 860 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor-interacting SERINE/THREONINE-protein kinase 2
- EC
- 2.7.11.1, 2.7.10.2
- UniProt
- O43353
- Pockets
- 7 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 50% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| F, A, B, C, D, E, G, H, I, J | Receptor-interacting SERINE/THREONINE-protein kinase 2 (EC 2.7.11.1, 2.7.10.2) | protein | 86 | 50% helix, 0% strand | O43353 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 738 | 0.84 | 0.87 | 112 | empty |
| 2 | 401 | 0.77 | 0.86 | 63 | empty |
| 3 | 192 | 0.70 | 0.88 | 36 | empty |
| 4 | 64 | 0.48 | 0.85 | 14 | empty |
| 5 | 92 | 0.41 | 0.78 | 20 | empty |
Interfaces
22 interfaces between chains.
- A–E · 480 Ų buried · 2 hydrogen bonds · protein-protein
- F–J · 478 Ų buried · 2 hydrogen bonds · protein-protein
- E–I · 477 Ų buried · 2 hydrogen bonds · protein-protein
- F–B · 476 Ų buried · 2 hydrogen bonds · protein-protein
- C–G · 474 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6GGS · Structure of RIP2 CARD filament · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43353
- Elsewhere: RCSB PDB 6GGS · PDBe 6GGS · UniProt O43353
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