MolNFT v1 · #149952 · protein
Structure of the BTB/POZ domain of human 90K
6GFB · Galectin-3-binding protein: “Structure of the BTB/POZ domain of human 90K”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.29). MolNFT v1 #149952 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6GFB
- Type
- protein
- Length
- 242 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Galectin-3-binding protein
- UniProt
- Q08380
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.29
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Galectin-3-binding protein | protein | 119 | 51% helix, 24% strand | Q08380 |
| B | Galectin-3-binding protein | protein | 123 | 53% helix, 24% strand | Q08380 |
Ligands and binding sites
- ZN · Zinc ion · metal · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.29 | 0.73 | 14 | empty |
| 2 | 63 | 0.27 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1521 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08380
- Elsewhere: RCSB PDB 6GFB · PDBe 6GFB · UniProt Q08380
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