MolNFT v1 · #149839 · protein
Crystal structure of trx-like and nhl repeat containing domains of human NHLRC2
6GC1 · Nhl repeat-containing protein 2: “Crystal structure of trx-like and nhl repeat containing domains of human NHLRC2”. X-ray diffraction, 20 pockets (best druggability 0.73). MolNFT v1 #149839 on GenesisL1: 3D structure, binding sites…
- PDB
- 6GC1
- Type
- protein
- Length
- 2,194 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nhl repeat-containing protein 2
- UniProt
- Q8NBF2
- Pockets
- 20 · best druggability 0.73
Structure
x-ray diffraction · 4 distinct chains · 19% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nhl repeat-containing protein 2 | protein | 549 | 19% helix, 34% strand | Q8NBF2 |
| B | Nhl repeat-containing protein 2 | protein | 546 | 19% helix, 34% strand | Q8NBF2 |
| C | Nhl repeat-containing protein 2 | protein | 551 | 19% helix, 34% strand | Q8NBF2 |
| D | Nhl repeat-containing protein 2 | protein | 548 | 19% helix, 34% strand | Q8NBF2 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 517 | 0.73 | 0.82 | 63 | empty |
| 2 | 296 | 0.70 | 0.84 | 40 | empty |
| 3 | 238 | 0.69 | 0.85 | 35 | empty |
| 4 | 374 | 0.69 | 0.81 | 45 | empty |
| 5 | 384 | 0.68 | 0.81 | 48 | empty |
Interfaces
4 interfaces between chains.
- A–C · 476 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 401 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 395 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 386 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6GC1 · Crystal structure of Trx-like and NHL repeat containing domains of human NHLRC2 · the same entry in another collection · chain D against D, TM-score 1.00
- Q8NBF2 · AlphaFold monomer V2.0 prediction for nhl repeat-containing protein 2 (Q8NBF2) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NBF2
- Elsewhere: RCSB PDB 6GC1 · PDBe 6GC1 · UniProt Q8NBF2
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