MolNFT v1 · #149616 · protein

The structure of a carbohydrate active P450

6G5O · Cytochrome P450: “The structure of a carbohydrate active P450”. X-ray diffraction, 1 ligand (HEM), 3 pockets (best druggability 0.82). MolNFT v1 #149616 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6G5O
Type: protein
Length: 747 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytochrome P450
EC: 1.14.15.-
UniProt: G0L713
Ligands: HEM
Pockets: 3 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 49% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytochrome P450 (EC 1.14.15.-)	protein	372	49% helix, 17% strand	G0L713
B	Cytochrome P450 (EC 1.14.15.-)	protein	375	49% helix, 17% strand	G0L713

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	943	0.82	0.84	84	HEM
2	809	0.81	0.84	77	HEM
3	340	0.53	0.74	37	empty

Interfaces

1 interface between chains.

A–B · 153 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

6G5O · The structure of a carbohydrate active P450 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0L713
Elsewhere: RCSB PDB 6G5O · PDBe 6G5O · UniProt G0L713

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