MolNFT v1 · #149537 · protein
Crystal structure of edds lyase in complex with succinate
6G3G · Argininosuccinate lyase: “Crystal structure of edds lyase in complex with succinate”. X-ray diffraction, 5 pockets (best druggability 0.51). MolNFT v1 #149537 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6G3G
- Type
- protein
- Length
- 497 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Argininosuccinate lyase
- UniProt
- Q11KV9
- Pockets
- 5 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 69% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Argininosuccinate lyase | protein | 497 | 69% helix, 4% strand | Q11KV9 |
Ligands and binding sites
- PEG · Di(hydroxyethyl)ether · additive · 8 copies · chains A
- SIN · Succinic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 142 | 0.51 | 0.79 | 23 | empty |
| 2 | 59 | 0.41 | 0.81 | 17 | PEG |
| 3 | 85 | 0.37 | 0.77 | 17 | empty |
| 4 | 70 | 0.33 | 0.75 | 15 | empty |
| 5 | 52 | 0.25 | 0.73 | 9 | empty |
Compared structures
- 6G3G · Crystal structure of EDDS lyase in complex with succinate · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q11KV9
- Elsewhere: RCSB PDB 6G3G · PDBe 6G3G · UniProt Q11KV9
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