Crystal structure of the first bromodomain of human BRD4 in complex with an acetylated GATA1 peptide (K312AC/K315AC)

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 0% strand (DSSP).

Ligands and binding sites

• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 631 Ų buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (acetylation).

Compared structures

• 6G0Q · Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated… · the same entry in another collection · chain A against A, TM-score 1.00
• O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.97
• P15976 · AlphaFold monomer V2.0 prediction for erythroid transcription factor (P15976) · a predicted model of the same protein · chain B against A, TM-score 0.29

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O60885
• Every structure of UniProt P15976
• Elsewhere: RCSB PDB 6G0Q · PDBe 6G0Q · UniProt O60885 · UniProt P15976