MolNFT v1 · #149433 · protein

BRD4 (BD1) in complex with apsc-derived ligands

6G0E: “BRD4 (BD1) in complex with apsc-derived ligands”. X-ray diffraction, 2 ligands (EGN, NA). MolNFT v1 #149433 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6G0E
Type: protein
Length: 125 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: O60885
Ligands: EGN, NA

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	125	—	O60885

Ligands and binding sites

EGN · 4-[2-(4-cyclohexylpiperazin-4-ium-1-yl)-2-oxidanylidene-ethyl]sulfanyl-1-ethyl-quinolin-2-one · ligand · chains A
NA · Sodium ion · metal · 2 copies · chains A
FMT · Formic acid · additive · 2 copies · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6G0E · BRD4 (BD1) in complex with APSC-derived ligands · the same entry in another collection · chain A against A, TM-score 1.00
O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O60885
Elsewhere: RCSB PDB 6G0E · PDBe 6G0E · UniProt O60885

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