MolNFT v1 · #149419 · protein
PPAR MUTANT
6FZY · Peroxisome proliferator-activated receptor gamma: “PPAR MUTANT”. X-ray diffraction, 12 pockets (best druggability 0.81). MolNFT v1 #149419 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6FZY
- Type
- protein
- Length
- 539 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peroxisome proliferator-activated receptor gamma
- UniProt
- P37231
- Pockets
- 12 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 66% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peroxisome proliferator-activated receptor gamma | protein | 270 | 66% helix, 4% strand | P37231 |
| B | Peroxisome proliferator-activated receptor gamma | protein | 269 | 66% helix, 4% strand | P37231 |
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 443 | 0.81 | 0.89 | 44 | empty |
| 2 | 618 | 0.79 | 0.84 | 71 | empty |
| 3 | 110 | 0.56 | 0.85 | 25 | empty |
| 4 | 277 | 0.54 | 0.76 | 38 | empty |
| 5 | 118 | 0.50 | 0.80 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1381 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 6FZY · PPAR mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37231
- Elsewhere: RCSB PDB 6FZY · PDBe 6FZY · UniProt P37231
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