MolNFT v1 · #149410 · protein
Ppar gamma complex.
6FZP · Peroxisome proliferator-activated receptor gamma: “Ppar gamma complex.”. X-ray diffraction, 1 ligand (EDK), 1 pocket (best druggability 0.85). MolNFT v1 #149410 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6FZP
- Type
- protein
- Length
- 267 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peroxisome proliferator-activated receptor gamma; Peroxisome proliferator-activated…
- UniProt
- P37231, Q9UBK2
- Ligands
- EDK
- Pockets
- 1 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 64% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peroxisome proliferator-activated receptor gamma | protein | 258 | 64% helix, 5% strand | P37231 |
| C | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | protein | 9 | 67% helix, 0% strand | Q9UBK2 |
Ligands and binding sites
- EDK · (2~{S})-3-[4-[2-[methyl(pyridin-2-yl) amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl) phenyl]amino]propanoic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 461 | 0.85 | 0.92 | 53 | EDK |
Interfaces
1 interface between chains.
- A–C · 516 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37231
- Every structure of UniProt Q9UBK2
- Elsewhere: RCSB PDB 6FZP · PDBe 6FZP · UniProt P37231 · UniProt Q9UBK2
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