MolNFT v1 · #14936 · protein

W224H variant of S. enterica rmla

1MP4 · W224H variant of S. enterica rmla bound to udp-glucose: “W224H variant of S. enterica rmla”. X-ray diffraction, 1 ligand (UPG), 8 pockets (best druggability 0.74). MolNFT v1 #14936 on GenesisL1: 3D structure, binding sites and…

PDB: 1MP4
Type: protein
Length: 578 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: W224H variant of S. enterica rmla bound to udp-glucose
EC: 2.7.7.24
UniProt: Q9F7G8
Ligands: UPG
Pockets: 8 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	W224H variant of S. enterica rmla bound to udp-glucose (EC 2.7.7.24)	protein	289	38% helix, 21% strand	Q9F7G8

Ligands and binding sites

UPG · Uridine-5'-diphosphate-glucose · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	59	0.74	0.99	15	empty
2	589	0.73	0.81	52	UPG
3	562	0.71	0.80	54	UPG
4	135	0.46	0.77	20	empty
5	148	0.46	0.77	20	empty

Interfaces

1 interface between chains.

A–B · 1412 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

1MP4 · W224H VARIANT OF S. ENTERICA RmlA · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9F7G8
Elsewhere: RCSB PDB 1MP4 · PDBe 1MP4 · UniProt Q9F7G8

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.