MolNFT v1 · #149312 · protein
Crystal structure of human wild type beta-1,4-galactosyltransferase-1 (B4GALT1) in apo-closed dimeric form
6FWU · Beta-1,4-galactosyltransferase 1: “Crystal structure of human wild type beta-1,4-galactosyltransferase-1 (B4GALT1) in apo-closed dimeric form”. X-ray diffraction, 1 ligand (NO3), 6 pockets (best druggability 0.70). MolNFT v1 #149312…
- PDB
- 6FWU
- Type
- protein
- Length
- 504 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-1,4-galactosyltransferase 1
- EC
- 2.4.1.-, 2.4.1.22, 2.4.1.90, 2.4.1.38
- UniProt
- P15291
- Ligands
- NO3
- Pockets
- 6 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-1,4-galactosyltransferase 1 (EC 2.4.1.-, 2.4.1.22, 2.4.1.90, 2.4.1.38) | protein | 253 | 26% helix, 23% strand | P15291 |
| B | Beta-1,4-galactosyltransferase 1 (EC 2.4.1.-, 2.4.1.22, 2.4.1.90, 2.4.1.38) | protein | 251 | 25% helix, 24% strand | P15291 |
Ligands and binding sites
- NO3 · Nitrate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 231 | 0.70 | 0.86 | 46 | empty |
| 2 | 253 | 0.68 | 0.84 | 32 | empty |
| 3 | 208 | 0.61 | 0.82 | 28 | empty |
| 4 | 74 | 0.50 | 0.84 | 19 | empty |
| 5 | 87 | 0.49 | 0.82 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 690 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6FWU · Crystal structure of human wild type beta-1,4-galactosyltransferase-1 (B4GalT1) in… · the same entry in another collection · chain A against A, TM-score 1.00
- P15291 · AlphaFold monomer V2.0 prediction for beta-1,4-galactosyltransferase 1 (P15291) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15291
- Elsewhere: RCSB PDB 6FWU · PDBe 6FWU · UniProt P15291
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