MolNFT v1 · #149238 · protein
Complement factor D in complex with the inhibitor 3-((3-((3- (AMINOMETHYL)PHENYL)AMINO)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YL)AMINO) phenol
6FUI: “Complement factor D in complex with the inhibitor 3-((3-((3…”. X-ray diffraction, 1 ligand (E7W), 1 pocket (best druggability 0.51). MolNFT v1 #149238 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6FUI
- Type
- protein
- Length
- 227 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Complement factor D
- EC
- 3.4.21.46
- UniProt
- P00746
- Ligands
- E7W
- Pockets
- 1 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Complement factor D (EC 3.4.21.46) | protein | 227 | 8% helix, 37% strand | P00746 |
Ligands and binding sites
- E7W · (1~{R},2~{S})-2-[[4-[[3-(aminomethyl) phenyl]amino]quinazolin-2-yl]amino]cyclohexane-1-carboxylic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 142 | 0.51 | 0.80 | 30 | E7W |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00746
- Elsewhere: RCSB PDB 6FUI · PDBe 6FUI · UniProt P00746
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