MolNFT v1 · #149237 · protein

Complement factor D in complex with the inhibitor (4-((3- (AMINOMETHYL)PHENYL)AMINO)QUINAZOLIN-2-yl)-L-valine

6FUH: “Complement factor D in complex with the inhibitor (4-((3- (AMINOMETHYL)PHENYL)AMINO)QUINAZOLIN-2-yl)-L-valine”. X-ray diffraction, 1 ligand (E88). MolNFT v1 #149237 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6FUH
Type: protein
Length: 228 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P00746
Ligands: E88

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	228	—	P00746

Ligands and binding sites

E88 · (2~{S})-2-[[4-[[3-(aminomethyl)phenyl]amino]quinazolin-2-yl]amino]-3-methyl-butanoic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6FUH · Complement factor D in complex with the inhibitor… · the same entry in another collection · chain A against A, TM-score 1.00
P00746 · AlphaFold monomer V2.0 prediction for complement factor D (P00746) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00746
Elsewhere: RCSB PDB 6FUH · PDBe 6FUH · UniProt P00746

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