MolNFT v1 · #149219 · protein
Complement factor D complexed with compound 6
6FTZ: “Complement factor D complexed with compound 6”. X-ray diffraction, 1 ligand (E7E), 1 pocket (best druggability 0.50). MolNFT v1 #149219 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6FTZ
- Type
- protein
- Length
- 228 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Complement factor D
- EC
- 3.4.21.46
- UniProt
- P00746
- Ligands
- E7E
- Pockets
- 1 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Complement factor D (EC 3.4.21.46) | protein | 228 | 8% helix, 35% strand | P00746 |
Ligands and binding sites
- E7E · ~{N}4-[3-(aminomethyl)phenyl]-1~{H}-indole-2,4-dicarboxamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 153 | 0.50 | 0.79 | 32 | E7E |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00746
- Elsewhere: RCSB PDB 6FTZ · PDBe 6FTZ · UniProt P00746
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.