MolNFT v1 · #149210 · protein

Crystal structure of human beta-ureidopropionase (beta-alanine synthase) - mutant T299C

6FTQ: “Crystal structure of human beta-ureidopropionase (beta-alanine synthase) - mutant T299C”. X-ray diffraction, 5 pockets (best druggability 0.51). MolNFT v1 #149210 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6FTQ
Type: protein
Length: 332 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-ureidopropionase
EC: 3.5.1.6
UniProt: Q9UBR1
Pockets: 5 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-ureidopropionase (EC 3.5.1.6)	protein	332	32% helix, 25% strand	Q9UBR1

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	64	0.51	0.85	17	empty
2	120	0.47	0.79	20	empty
3	59	0.39	0.80	17	empty
4	79	0.36	0.77	19	empty
5	60	0.29	0.74	17	empty

Modifications

Observed in the structure: 1 disulfide, 1 modified (disulfide, oxidation).

Compared structures

6FTQ · Crystal structure of human beta-ureidopropionase (beta-alanine synthase) - mutant T299C · the same entry in another collection · chain A against A, TM-score 1.00
Q9UBR1 · AlphaFold monomer V2.0 prediction for beta-ureidopropionase (Q9UBR1) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UBR1
Elsewhere: RCSB PDB 6FTQ · PDBe 6FTQ · UniProt Q9UBR1

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