MolNFT v1 · #149202 · protein

Regulatory subunit of a camp-independent protein kinase a from trypanosoma cruzi at 1.09 a resolution

6FTF · Protein kinase a regulatory subunit, putative: “Regulatory subunit of a camp-independent protein kinase a from trypanosoma cruzi at 1.09 a resolution”. X-ray diffraction, 1 ligand (7CI), 4 pockets (best druggability 0.76). MolNFT v1…

PDB: 6FTF
Type: protein
Length: 291 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein kinase a regulatory subunit, putative
UniProt: Q4DSV5
Ligands: 7CI
Pockets: 4 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Protein kinase a regulatory subunit, putative	protein	291	36% helix, 30% strand	Q4DSV5

Ligands and binding sites

7CI · 7-cyano-7-deazainosine · ligand · 2 copies · chains B
EDO · 1,2-ethanediol · additive · 3 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	99	0.76	0.96	21	7CI
2	105	0.57	0.84	23	7CI
3	125	0.39	0.74	22	empty
4	55	0.32	0.77	14	empty

Compared structures

6FTF · Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi at 1.09… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4DSV5
Elsewhere: RCSB PDB 6FTF · PDBe 6FTF · UniProt Q4DSV5

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.