MolNFT v1 · #148949 · protein
Regulatory subunit of a camp-independent protein kinase a from trypanosoma brucei at 2.1 ångström resolution
6FLO · Protein kinase a regulatory subunit: “Regulatory subunit of a camp-independent protein kinase a from trypanosoma brucei at 2.1 ångström resolution”. X-ray diffraction, 1 ligand (NOS), 10 pockets (best druggability 0.76). MolNFT v1…
- PDB
- 6FLO
- Type
- protein
- Length
- 549 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein kinase a regulatory subunit
- UniProt
- Q9GU80
- Ligands
- NOS
- Pockets
- 10 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein kinase a regulatory subunit | protein | 277 | 37% helix, 29% strand | Q9GU80 |
| B | Protein kinase a regulatory subunit | protein | 272 | 36% helix, 30% strand | Q9GU80 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.76 | 0.97 | 20 | NOS |
| 2 | 96 | 0.76 | 0.96 | 21 | NOS |
| 3 | 293 | 0.60 | 0.78 | 46 | NOS |
| 4 | 106 | 0.59 | 0.86 | 23 | NOS |
| 5 | 284 | 0.53 | 0.75 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 695 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6FLO · Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei at 2.1… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9GU80
- Elsewhere: RCSB PDB 6FLO · PDBe 6FLO · UniProt Q9GU80
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