MolNFT v1 · #14882 · protein
Alteration of axial coordination by protein engineering in myoglobin. bis-imidazole ligation in the HIS64-- >VAL(SLASH)VAL68-->his double mutant
1MNI: “Alteration of axial coordination by protein engineering in myoglobin. bis-imidazole ligation in the HIS64…”. X-ray diffraction, 1 ligand (HEM), 2 pockets (best druggability 0.73). MolNFT v1 #14882 on GenesisL1: 3D structure, binding…
- PDB
- 1MNI
- Type
- protein
- Length
- 306 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myoglobin
- UniProt
- P02189
- Ligands
- HEM
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Myoglobin | protein | 153 | 76% helix, 0% strand | P02189 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 197 | 0.73 | 0.89 | 30 | HEM |
| 2 | 208 | 0.71 | 0.87 | 28 | HEM |
Interfaces
1 interface between chains.
- A–B · 87 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 1MNI · Alteration of axial coordination by protein engineering in myoglobin. bis-imidazole… · the same entry in another collection · chain A against A, TM-score 1.00
- P02189 · AlphaFold monomer V2.0 prediction for myoglobin (P02189) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02189
- Elsewhere: RCSB PDB 1MNI · PDBe 1MNI · UniProt P02189
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