MolNFT v1 · #1488 · protein

Human serum transferrin, N-terminal lobe, expressed in pichia pastoris

1B3E · Protein (serum transferrin): “Human serum transferrin, N-terminal lobe, expressed in pichia pastoris”. X-ray diffraction, 2 ligands (FE, CO3), 3 pockets (best druggability 0.74). MolNFT v1 #1488 on GenesisL1: 3D structure, binding…

PDB: 1B3E
Type: protein
Length: 330 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (serum transferrin)
UniProt: P02787
Ligands: FE, CO3
Pockets: 3 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (serum transferrin)	protein	330	34% helix, 22% strand	P02787

Ligands and binding sites

FE · Fe (III) ion · metal · chains A
CO3 · Carbonate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	232	0.74	0.89	44	empty
2	62	0.35	0.77	16	empty
3	72	0.32	0.74	16	empty

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

1B3E · Human serum transferrin, N-terminal lobe, expressed in pichia pastoris · the same entry in another collection · chain A against A, TM-score 1.00
P02787 · AlphaFold monomer V2.0 prediction for serotransferrin (P02787) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02787
Elsewhere: RCSB PDB 1B3E · PDBe 1B3E · UniProt P02787

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