MolNFT v1 · #148678 · protein

Crystal structure of the nyn domain of human MARF1

6FDL · Meiosis regulator and mRNA stability factor 1: “Crystal structure of the nyn domain of human MARF1”. X-ray diffraction, 1 pocket (best druggability 0.74). MolNFT v1 #148678 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6FDL
Type: protein
Length: 301 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Meiosis regulator and mRNA stability factor 1
UniProt: Q9Y4F3
Pockets: 1 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Meiosis regulator and mRNA stability factor 1	protein	151	37% helix, 26% strand	Q9Y4F3
B	Meiosis regulator and mRNA stability factor 1	protein	150	41% helix, 25% strand	Q9Y4F3

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	72	0.74	0.98	23	empty

Interfaces

1 interface between chains.

A–B · 1248 Å² buried · 26 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

6FDL · Crystal structure of the NYN domain of human MARF1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y4F3 · AlphaFold monomer V2.0 prediction for meiosis regulator and mRNA stability factor 1… · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y4F3
Elsewhere: RCSB PDB 6FDL · PDBe 6FDL · UniProt Q9Y4F3

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