MolNFT v1 · #148622 · protein

Crystal structure of the EIF4E-EIF4G complex from chaetomium thermophilum

6FC0 · Eukaryotic translation initiation factor 4E-like protein: “Crystal structure of the EIF4E-EIF4G complex from chaetomium thermophilum”. X-ray diffraction, 3 pockets (best druggability 0.33). MolNFT v1 #148622 on GenesisL1: 3D…

PDB: 6FC0
Type: protein
Length: 269 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Eukaryotic translation initiation factor 4E-like protein; Eukaryotic translation…
UniProt: G0SCU4, G0SFP0
Pockets: 3 · best druggability 0.33

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Eukaryotic translation initiation factor 4E-like protein	protein	192	22% helix, 29% strand	G0SCU4
B	Eukaryotic translation initiation factor 4G	protein	77	35% helix, 3% strand	G0SFP0

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	80	0.33	0.75	20	empty
2	63	0.33	0.75	18	empty
3	67	0.29	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 2221 Å² buried · 32 hydrogen bonds · protein-protein

Compared structures

6FC0 · Crystal structure of the eIF4E-eIF4G complex from Chaetomium thermophilum · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0SCU4
Every structure of UniProt G0SFP0
Elsewhere: RCSB PDB 6FC0 · PDBe 6FC0 · UniProt G0SCU4 · UniProt G0SFP0

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