MolNFT v1 · #148539 · protein

The LIPY/F-motif in an intracellular subtilisin protease is involved in inhibition

6F9M · Serine protease: “The LIPY/F-motif in an intracellular subtilisin protease is involved in inhibition”. X-ray diffraction, 1 ligand (NA), 2 pockets (best druggability 0.69). MolNFT v1 #148539 on GenesisL1: 3D structure, binding sites…

PDB: 6F9M
Type: protein
Length: 587 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serine protease
Ligands: NA
Pockets: 2 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serine protease	protein	293	32% helix, 22% strand	—
B	Serine protease	protein	294	32% helix, 22% strand	—

Ligands and binding sites

NA · Sodium ion · metal · 2 copies · chains A, B
PGE · Triethylene glycol · additive · 2 copies · chains A, B
ACT · Acetate ion · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	304	0.69	0.83	50	PGE
2	169	0.45	0.75	37	empty

Interfaces

1 interface between chains.

A–B · 1060 Å² buried · 22 hydrogen bonds · protein-protein

Compared structures

6F9M · The LIPY/F-motif in an intracellular subtilisin protease is involved in inhibition · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6F9M · PDBe 6F9M

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