MolNFT v1 · #14851 · protein

Distinct metal environment in iron-substituted manganese superoxide dismutase provides a structural basis of metal specificity

1MMM · Protein (iron-substituted manganese superoxide dismutase): “Distinct metal environment in iron-substituted manganese superoxide dismutase provides a structural basis of…”. X-ray diffraction, 2 ligands (FE, OH), 3 pockets (best…

PDB: 1MMM
Type: protein
Length: 410 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (iron-substituted manganese superoxide dismutase)
EC: 1.15.1.1
UniProt: P00448
Ligands: FE, OH
Pockets: 3 · best druggability 0.54

Structure

x-ray diffraction · 1 distinct chain · 57% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Protein (iron-substituted manganese superoxide dismutase) (EC 1.15.1.1)	protein	205	57% helix, 12% strand	P00448

Ligands and binding sites

FE · Fe (III) ion · metal · 2 copies · chains A, B
OH · Hydroxide ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	189	0.54	0.79	21	empty
2	167	0.53	0.80	19	empty
3	55	0.24	0.72	16	empty

Interfaces

1 interface between chains.

A–B · 906 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

1MMM · Distinct metal environment in iron-substituted manganese superoxide dismutase provides a… · the same entry in another collection · chain A against A, TM-score 1.00
P00448 · AlphaFold monomer V2.0 prediction for superoxide dismutase [mn] (P00448) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00448
Elsewhere: RCSB PDB 1MMM · PDBe 1MMM · UniProt P00448

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