MolNFT v1 · #148365 · protein

Crystal structure of drosophila melanogaster snf

6F4I · U1 small nuclear ribonucleoprotein a: “Crystal structure of drosophila melanogaster snf”. X-ray diffraction, 3 pockets (best druggability 0.82). MolNFT v1 #148365 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6F4I
Type: protein
Length: 528 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: U1 small nuclear ribonucleoprotein a
UniProt: P43332
Pockets: 3 · best druggability 0.82

Structure

x-ray diffraction · 6 distinct chains · 37% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	U1 small nuclear ribonucleoprotein a	protein	92	38% helix, 25% strand	P43332
B	U1 small nuclear ribonucleoprotein a	protein	92	40% helix, 25% strand	P43332
C	U1 small nuclear ribonucleoprotein a	protein	83	35% helix, 28% strand	P43332
D	U1 small nuclear ribonucleoprotein a	protein	86	43% helix, 26% strand	P43332
E	U1 small nuclear ribonucleoprotein a	protein	81	32% helix, 30% strand	P43332
F	U1 small nuclear ribonucleoprotein a	protein	94	35% helix, 24% strand	P43332

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	999	0.82	0.83	78	empty
2	646	0.74	0.80	46	empty
3	246	0.51	0.75	39	empty

Interfaces

11 interfaces between chains.

D–E · 628 Å² buried · 4 hydrogen bonds · protein-protein
C–F · 618 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 615 Å² buried · 5 hydrogen bonds · protein-protein
A–C · 360 Å² buried · 7 hydrogen bonds · protein-protein
C–E · 349 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

6F4I · Crystal structure of Drosophila melanogaster SNF · the same entry in another collection · chain F against F, TM-score 1.00
P43332 · AlphaFold monomer V2.0 prediction for U1 small nuclear ribonucleoprotein a (P43332) · a predicted model of the same protein · chain C against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43332
Elsewhere: RCSB PDB 6F4I · PDBe 6F4I · UniProt P43332

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