MolNFT v1 · #148356 · protein
Periplasmic domain of lolc lacking the hook.
6F49 · Lipoprotein-releasing system transmembrane protein lolc…: “Periplasmic domain of lolc lacking the hook.”. X-ray diffraction, 10 pockets (best druggability 0.73). MolNFT v1 #148356 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6F49
- Type
- protein
- Length
- 841 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lipoprotein-releasing system transmembrane protein lolc, lipoprotein-releasing system…
- UniProt
- P0ADC3
- Pockets
- 10 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 31% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lipoprotein-releasing system transmembrane protein lolc, lipoprotein-releasing system transmembrane protein lolc | protein | 208 | 30% helix, 34% strand | P0ADC3 |
| B | Lipoprotein-releasing system transmembrane protein lolc, lipoprotein-releasing system transmembrane protein lolc | protein | 209 | 31% helix, 34% strand | P0ADC3 |
| C, D | Lipoprotein-releasing system transmembrane protein lolc, lipoprotein-releasing system transmembrane protein lolc | protein | 212 | 31% helix, 33% strand | P0ADC3 |
Ligands and binding sites
- GOL · Glycerol · additive · 10 copies · chains A, B, C, D
- PG5 · 1-methoxy-2-[2-(2-methoxy-ethoxy]-ethane · additive · 2 copies · chains B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 462 | 0.73 | 0.82 | 52 | GOL |
| 2 | 423 | 0.72 | 0.83 | 33 | GOL |
| 3 | 72 | 0.59 | 0.89 | 23 | empty |
| 4 | 123 | 0.51 | 0.81 | 23 | GOL |
| 5 | 136 | 0.50 | 0.80 | 24 | GOL |
Interfaces
4 interfaces between chains.
- C–D · 1406 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 1397 Ų buried · 19 hydrogen bonds · protein-protein
- A–D · 470 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 369 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0ADC3
- Elsewhere: RCSB PDB 6F49 · PDBe 6F49 · UniProt P0ADC3
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