MolNFT v1 · #148289 · protein
A flipqr complex forms the core of the salmonella type III secretion system export apparatus.
6F2D · Flagellar biosynthetic protein flip: “A flipqr complex forms the core of the salmonella type III secretion system export apparatus.”. Electron microscopy, 20 pockets (best druggability 0.88). MolNFT v1 #148289 on GenesisL1: 3D…
- PDB
- 6F2D
- Type
- protein
- Length
- 1,629 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Flagellar biosynthetic protein flip; Flagellar biosynthetic protein flir; Flagellar…
- UniProt
- G5QE81, P54702, P0A1L6
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 3 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Flagellar biosynthetic protein flip | protein | 203 | 72% helix, 0% strand | G5QE81 |
| F | Flagellar biosynthetic protein flir | protein | 258 | 68% helix, 0% strand | P54702 |
| G, H, I, J | Flagellar biosynthetic protein fliq | protein | 89 | 80% helix, 0% strand | P0A1L6 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 753 | 0.88 | 0.91 | 104 | empty |
| 2 | 788 | 0.88 | 0.90 | 90 | empty |
| 3 | 595 | 0.85 | 0.90 | 62 | empty |
| 4 | 617 | 0.84 | 0.88 | 84 | empty |
| 5 | 960 | 0.83 | 0.85 | 98 | empty |
Interfaces
30 interfaces between chains.
- E–F · 2169 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 1897 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 1860 Ų buried · 2 hydrogen bonds · protein-protein
- A–F · 1759 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 1707 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 6F2D · A FliPQR complex forms the core of the Salmonella type III secretion system export… · the same entry in another collection · chain J against J, TM-score 1.00
- P54702 · AlphaFold monomer V2.0 prediction for flagellar biosynthetic protein flir (P54702) · a predicted model of the same protein · chain F against A, TM-score 0.88
- P0A1L6 · AlphaFold monomer V2.0 prediction for flagellar biosynthetic protein fliq (P0A1L6) · a predicted model of the same protein · chain H against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G5QE81
- Every structure of UniProt P54702
- Every structure of UniProt P0A1L6
- Elsewhere: RCSB PDB 6F2D · PDBe 6F2D · UniProt G5QE81 · UniProt P54702 · UniProt P0A1L6
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