MolNFT v1 · #148221 · protein

Structure of yeast SEC14P with a picolinamide compound

6F0E · SEC14 cytosolic factor: “Structure of yeast SEC14P with a picolinamide compound”. X-ray diffraction, 1 ligand (C8K), 3 pockets (best druggability 0.71). MolNFT v1 #148221 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6F0E
Type: protein
Length: 300 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SEC14 cytosolic factor
UniProt: P24280
Ligands: C8K
Pockets: 3 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SEC14 cytosolic factor	protein	300	53% helix, 10% strand	P24280

Ligands and binding sites

C8K · ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-bromanyl-3-fluoranyl-pyridine-2-carboxamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	513	0.71	0.80	64	C8K
2	349	0.64	0.79	43	empty
3	232	0.59	0.80	22	empty

Compared structures

6F0E · Structure of yeast Sec14p with a picolinamide compound · the same entry in another collection · chain A against A, TM-score 1.00
P24280 · AlphaFold monomer V2.0 prediction for SEC14 cytosolic factor (P24280) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P24280
Elsewhere: RCSB PDB 6F0E · PDBe 6F0E · UniProt P24280

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