MolNFT v1 · #148138 · protein
Prolyl hydroxylase from trichoplax adhaerens
6EY1 · Hif prolyl hydroxylase: “Prolyl hydroxylase from trichoplax adhaerens”. X-ray diffraction, 1 ligand (MN), 2 pockets (best druggability 0.68). MolNFT v1 #148138 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6EY1
- Type
- protein
- Length
- 211 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hif prolyl hydroxylase
- UniProt
- I6QVT6
- Ligands
- MN
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hif prolyl hydroxylase | protein | 211 | 31% helix, 31% strand | I6QVT6 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · chains A
- ACT · Acetate ion · additive · 3 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 105 | 0.68 | 0.91 | 24 | ACT, MN |
| 2 | 126 | 0.50 | 0.79 | 19 | ACT |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6EY1 · prolyl hydroxylase from Trichoplax adhaerens · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I6QVT6
- Elsewhere: RCSB PDB 6EY1 · PDBe 6EY1 · UniProt I6QVT6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.