MolNFT v1 · #148126 · protein
Crystal structure of the SIRV3 ACRID1 (GP02) anti-CRISPR protein
6EXP: “Crystal structure of the SIRV3 ACRID1 (GP02) anti-CRISPR protein”. X-ray diffraction, 3 pockets (best druggability 0.63). MolNFT v1 #148126 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6EXP
- Type
- protein
- Length
- 591 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SIRV3 ACRID1 (GP02) anti-CRISPR protein
- UniProt
- A0A1B3SN05
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | SIRV3 ACRID1 (GP02) anti-CRISPR protein | protein | 96 | 21% helix, 58% strand | A0A1B3SN05 |
| B, D | SIRV3 ACRID1 (GP02) anti-CRISPR protein | protein | 100 | 20% helix, 57% strand | A0A1B3SN05 |
| F | SIRV3 ACRID1 (GP02) anti-CRISPR protein | protein | 103 | 19% helix, 54% strand | A0A1B3SN05 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 575 | 0.63 | 0.75 | 48 | empty |
| 2 | 138 | 0.40 | 0.74 | 20 | empty |
| 3 | 66 | 0.33 | 0.76 | 12 | empty |
Interfaces
7 interfaces between chains.
- C–D · 1016 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 990 Ų buried · 17 hydrogen bonds · protein-protein
- E–F · 989 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 272 Ų buried · 4 hydrogen bonds · protein-protein
- A–F · 233 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6EXP · Crystal structure of the SIRV3 AcrID1 (gp02) anti-CRISPR protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1B3SN05
- Elsewhere: RCSB PDB 6EXP · PDBe 6EXP · UniProt A0A1B3SN05
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